分子量:36.5 kDa

纯度:>92% as determined by reduced SDS-PAGE. 

内毒素:Less than 1.0 EU per μg of the Human Betacellulin, Fc Tag by the LAL method.

Buffer:50 mM tris, 100 mM glycine, pH7.5.

生物活性:

产品特性:Human Betacellulin, Fc Tag is fused with a human IgG1 Fc tag at the C-terminus, and has a calculated MW of 36.5 kDa. The predicted N-terminus is Asp 32. The reducing (R) protein migrates as 45-50 kDa in SDS-PAGE  due to glycosylation.

产品背景:Probetacellulin can be cleaved into the Betacellulin (BTC) that is a single-pass type I membrane protein containing 1 EGF-like domain. Predominantly expressed in pancreas and small intestine,Betacellulin (BTC) is synthesized primarily as a transmembrane precursor, which is then processed to mature molecule by proteolytic events. As a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells, Betacellulin (BTC) is also the growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Betacellulin (BTC) was originally identified as a growth-promoting factor in mouse pancreatic β-cell carcinoma cell line and has since been identified in humans. The amino acid sequence of mature mBTC is 82.5%, identical with that of human BTC (hBTC), and both exhibit significant overall similarity with other members of the EGF family.