分子量：Calculated MW: 120kDa
Observed MW: 150kDa

细胞定位：Cytoplasm, Nucleus, centrosome, cytoskeleton, microtubule organizing center, spindle pole

稀释方法：WB 1:500 - 1:2000
IHC 1:50 - 1:200

总结：This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression.