分子量：Calculated MW: 36kDa/42kDa
Observed MW: 49kDa

细胞定位：Mitochondrion inner membrane, Multi-pass membrane protein, Nucleus

稀释方法：WB 1:500 - 1:2000
IF 1:50 - 1:200

总结：This gene encodes a member of the rhomboid family of intramembrane serine proteases that is localized to the inner mitochondrial membrane. The encoded protein regulates mitochondrial remodeling and apoptosis through regulated substrate proteolysis. Proteolytic processing of the encoded protein results in the release of a small peptide, P-beta, which may transit to the nucleus. Mutations in this gene may be associated with Parkinson's disease.