Anti-STAT3 Monoclonal Antibody

商品货号：	商品品牌：	规格	基本售价：	选择规格
K000233M-50ul	solarbio	50ul	960.00元
K000233M-100ul	solarbio	100ul	1600.00元

英文名称	Anti-STAT3 Monoclonal Antibody
别名	ADMIO;ADMIO1;APRF;HIES;ADMIO;APRF;HIES
应用	WB IHC
稀释比例	WB 1:1000-2000. IHC 1:100-200.
交叉反应	Human Mouse Rat
蛋白分子量	79/86kDa
Gene ID	6774
保存	Store at -20°C. Avoid freeze / thaw cycles.
储存液	Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法	Saturated ammonium sulfate precipitation
亚型	IgG1
免疫原	Recombinant Protein
性状	液体
Public Immunogen Range	Recombinant Protein
Subcellular Locations	Cytoplasm Nucleus
Swiss Prot	P40763
克隆号	3F4
克隆类型	Monoclonal Antibody
背景资料	Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene . May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1. Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation (By similarity). May play an apoptotic role by transctivating BIRC5 expression under LEP activation . Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity.