Human Growth Factors & Cytokines
Recombinant Human Heregulin-β1 (HRG1-β)





 





		Synonyms :
Neuregulin1 (NRG1-β1), Neu differentiation factor (rat)



		Description :
Neuregulin/Heregulin is a family of structurally related polypeptide growth factors derived from alternatively spliced genes (NRG1, NRG2, NRG3 and NRG4).  To date, there are over 14 soluble and transmembrane proteins derived from the NRG1 gene.  Proteolytic processing of the extracellular domain of the transmembrane NRG1 isoforms release soluble growth factors.  HRG1-β1 contains an Ig domain and an EGF-like domain that is necessary for direct binding to receptor tyrosine kinases erb3 and erb4.  This binding induces erb3 and erb4 heterodimerization with erb2, stimulating intrinsic kinase activity, which leads to tyrosine phosphorylation.  Although HRG1-β1 biological effects is still unclear, it has been found to promote motility and invasiveness of breast cancer cells which may also involve up-regulation of expression and function of the autocrine motility-promoting factor (AMF).  Recombinant human Heregulin-β1 (HRG1-β1) is a 7.5 kDa polypeptide consisting of only the EGF domain of heregulin-β1 (65 amino acid residues).



		Catalog #:
100-03



		Source :
E.coli



		Purity :
Greater than 98% by SDS-PAGE gel and HPLC analyses.



		Endotoxin Level :
Endotoxin level is less than 0.1 ng per μg (1EU/μg).



		Biological Activity :
The ED50 was determined by the dose-dependent stimulation of the proliferation of human MCF-7 cells is ≤ 0.5 ng/ml, corresponding to a specific activity of ≥ 2 x 106 units/mg.


Selected References :
Selected List of References Citing This PeproTech Product



                AA Sequence :
SHLVKCAEKE KTFCVNGGEC FMVKDLSNPS RYLCKCPNEF TGDRCQNYVM ASFYKHLGIE FMEAE 



		PubMed Link :
Heregulin-beta1


Country of Origin :
USA
















        Size A
10μg
$80 
 


 



        Size B
50μg
$195 
 


 



        Size C
1mg
$1500 
 


 















Special 
                    Sizes: 
 Many products can be ordered in custom sizes. Please click here to contact Peprotech with your request.





Usage:
For Research Use Only.  Not for use in diagnostic or therapeutic procedures.