人活性Apg3全长蛋白信号转导蛋白-蛋白质/抗原/多肽-试剂-生物在线

产品名称：人活性Apg3全长蛋白信号转导蛋白

英文名称： 2610016C12Rik Apg 3 APG3 APG3 autophagy 3 like APG3 like APG3, S. cerevisiae, homolog of APG3-like APG3L Apg3p ATG 3 ATG3 ATG3 autophagy rel

产品编号： ab188738

产品价格： 0

产品产地：英国

品牌商标： abcam

更新时间： null

使用范围： null

深圳市宇德立生物科技有限公司

进入展台

Our Abpromise guarantee covers the use of ab188738 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

生物活性
Typical enzyme concentration to support conjugation in vitro is 100 nM-1 μM depending on conditions.
应用
SDS-PAGE

Functional Studies
纯度>95% by SDS-PAGE .
形式Liquid

别名
- 2610016C12Rik
- Apg 3
- APG3
see all
功能E2-like enzyme involved in autophagy and mitochondrial homeostasis. Catalyzes the conjugation of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A) to phosphatidylethanolamine (PE). PE-conjugation to ATG8-like proteins is essential for autophagy. Preferred substrate is MAP1LC3A. Also acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of ATG12 to itself, ATG12 conjugation to ATG3 playing a role in mitochondrial homeostasis but not in autophagy. ATG7 (E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with ATG3.
组织特异性Widely expressed, with a highest expression in heart, skeletal muscle, kidney, liver and placenta.
序列相似性Belongs to the ATG3 family.
翻译后修饰Conjugated to ATG12 at Lys-243. ATG12-conjugation plays a role in regulation of mitochondrial homeostasis and cell death, while it is not involved in PE-conjugation to ATG8-like proteins and autophagy.
细胞定位Cytoplasm.